SARS-CoV-2 Total Antibody, Spike, Semi-Quantitative Test
The SARS-CoV-2 Total Antibody, Spike, Semi-Quantitative test measures the level of antibodies against the SARS-CoV-2 spike protein in a blood sample. It is used as an aid in identifying an adaptive immune response from recent or prior infection, though it does not diagnose acute infection or measure immunity.
About this test
This test looks for antibodies the immune system makes against the spike protein of SARS-CoV-2, the virus that causes COVID-19. Quest describes it as measuring that antibody response on a semi-quantitative basis, meaning the result reflects a relative level rather than a simple positive or negative.
A result does not indicate the degree of immunity or protection from reinfection, and how long any antibody response persists is not established. For someone who has been vaccinated, Quest notes that the clinical significance of a positive result is not known.
Test details
| Quest code | 39820 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 1 mL serum |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
Quest lists this product under several names, including SARS, Coronavirus Total Antibody, Novel Coronavirus, COVID19, nCOV, COVID-19, COVID, ROCHE and Wuhan; all refer to the same semi-quantitative spike antibody measurement. The single analyte reported is the total antibody level against the SARS-CoV-2 spike protein, produced by an immunoassay run on a serum sample.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures the level of total antibody against the SARS-CoV-2 spike protein in a serum sample, on a semi-quantitative basis, using immunoassay methodology.
How is the sample collected?
The test uses a 1 mL serum sample from a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Does a positive result mean I'm protected from COVID-19?
No. Quest notes that results do not indicate the degree of immunity or protection from reinfection, and how long any antibody response lasts is not known.
What other names is this test listed under?
Quest lists it under names including SARS, Coronavirus Total Antibody, Novel Coronavirus, COVID19, nCOV, COVID-19, COVID, ROCHE and Wuhan.
Can I get the SARS-CoV-2 Total Antibody, Spike, Semi-Quantitative test without a doctor's visit or insurance?
Yes. The $279 cash price includes an independent physician's order, so no referral is needed, and insurance is never involved.