Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
This test measures immune antibodies targeting beta-2-glycoprotein I to help identify antiphospholipid syndrome and evaluate autoimmune clotting disorders. It measures IgG, IgA, and IgM antibody levels in a single plasma sample.
About this test
Beta-2-glycoprotein I, also called apolipoprotein H, is a protein that acts as a cofactor in antiphospholipid antibody binding. The test measures levels of IgG, IgA, and IgM antibodies directed against it.
The sample is plasma, collected in a sodium citrate tube, and is analyzed using immunoassay methodology. Because the test reports three separate antibody classes, a clinician reads the pattern across all three together with clinical history rather than any one value alone.
Test details
| Quest code | 30340 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 3 mL plasma |
| Collection | Quest patient service center |
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Additional details
What this test looks at
The test reports three separate values: IgG, IgA, and IgM antibodies to beta-2-glycoprotein I. Beta-2-glycoprotein I is described as the critical antigen involved in antiphospholipid antibody syndrome, serving as a cofactor in antiphospholipid antibody binding.
How it's often used alongside other tests
High titer IgG or IgM antibodies to beta-2-glycoprotein I are one of several criteria clinicians use when evaluating antiphospholipid antibody syndrome, so this test is typically read alongside other antiphospholipid antibody testing and a person's clinical history rather than on its own.
Order online. No doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures IgG, IgA, and IgM antibodies directed against beta-2-glycoprotein I, a cofactor involved in antiphospholipid antibody binding, using immunoassay methodology.
How is the sample collected?
The test uses a plasma sample, collected in a sodium citrate tube, through a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test. If a clinician has given you instructions, follow those.
Why might this test be ordered?
High titer IgG or IgM antibodies to beta-2-glycoprotein I are one of the criteria used in evaluating antiphospholipid antibody syndrome, an autoimmune clotting disorder.
What does a Beta-2-Glycoprotein I Antibodies test cost without insurance?
$569, including the doctor's order and Quest blood draw. The $25 fee is waived at $149+. See how ordering works and our blood test cost guide.