Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
This test measures immune antibodies targeting beta-2-glycoprotein I to help identify antiphospholipid syndrome and evaluate autoimmune clotting disorders. It measures IgG, IgA, and IgM antibody levels in a single plasma sample.
About this test
Beta-2-glycoprotein I, also called apolipoprotein H, is a protein that acts as a cofactor in antiphospholipid antibody binding. The test measures levels of IgG, IgA, and IgM antibodies directed against it.
The sample is plasma, collected in a sodium citrate tube, and is analyzed using immunoassay methodology. Because the test reports three separate antibody classes, a clinician reads the pattern across all three together with clinical history rather than any one value alone.
Test details
| Quest code | 30340 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 3 mL plasma |
| Collection | Quest patient service center |
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Additional details
What this test looks at
The test reports three separate values: IgG, IgA, and IgM antibodies to beta-2-glycoprotein I. Beta-2-glycoprotein I is described as the critical antigen involved in antiphospholipid antibody syndrome, serving as a cofactor in antiphospholipid antibody binding.
How it's often used alongside other tests
High titer IgG or IgM antibodies to beta-2-glycoprotein I are one of several criteria clinicians use when evaluating antiphospholipid antibody syndrome, so this test is typically read alongside other antiphospholipid antibody testing and a person's clinical history rather than on its own.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures IgG, IgA, and IgM antibodies directed against beta-2-glycoprotein I, a cofactor involved in antiphospholipid antibody binding, using immunoassay methodology.
How is the sample collected?
The test uses a plasma sample, collected in a sodium citrate tube, through a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Why might this test be ordered?
High titer IgG or IgM antibodies to beta-2-glycoprotein I are one of the criteria used in evaluating antiphospholipid antibody syndrome, an autoimmune clotting disorder.
What does a Beta-2-Glycoprotein I Antibodies test cost without insurance?
$569. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.