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Lab test

Mycoplasma pneumoniae Antibody Test (IgG, IgM)

This test measures IgG and IgM antibodies to Mycoplasma pneumoniae in a serum sample using immunoassay methodology. Quest describes it as a way to help identify this bacterium as a cause of respiratory tract infection.

Quest patient service center

About this test

Mycoplasma pneumoniae is a bacterium associated with respiratory tract infections, including community-acquired pneumonia, and testing may be considered especially in children. Quest notes that results may help guide antibiotic selection in children with suspected community-acquired pneumonia.

The test uses a 1 mL serum sample and immunoassay methodology to detect both IgG and IgM antibodies. Quest notes that false-negative results can occur, whether from a compromised immune system, testing before the antibody response has developed, or interfering substances in the serum sample.

Who might consider this test?

  • Read alongside clinical history and a physical exam
  • Such as culture or nucleic acid amplification testing

Test details

CollectionQuest patient service center

Quest resources

Additional details

What this test looks at

The test reports IgG and IgM antibody results separately from the same serum sample. Quest notes that a positive IgG result indicates previous or recent infection, while overall interpretation depends on the timing of the illness and the possibility of a false negative if testing happens before an antibody response develops.

This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this test measure?

It measures IgG and IgM antibodies to Mycoplasma pneumoniae in a serum sample, using immunoassay methodology.

How is the sample collected?

Through a routine blood draw that produces a serum sample.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Can a negative result rule out a Mycoplasma pneumoniae infection?

Not necessarily. Quest notes that false-negative results can occur, including when testing happens before an antibody response has developed, so a clinician weighs the result together with history and exam findings.

Is this the only way to test for Mycoplasma pneumoniae?

No. Quest notes that other methods, such as culture or nucleic acid amplification testing, are also used, and results across methods are interpreted together with clinical findings.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.