Neisseria meningitidis IgG Vaccine Response Test
This test measures serum IgG antibodies to four Neisseria meningitidis serogroups, A, C, W-135, and Y, and is used to evaluate a person's antibody response to meningococcal vaccination.
About this test
The test uses multi-analyte immunodetection to measure IgG antibodies that recognize polysaccharide antigens from the four serogroups contained in the licensed meningococcal vaccine. Quest describes it as a way to evaluate vaccine response by comparing antibody levels before and after vaccination, where a two-fold or greater rise in at least two serogroups is expected with an adequate response.
Because antibody levels change over time, Quest notes that levels are reported to peak about one month after vaccination and to decline markedly by two years afterward. That timing is part of why paired, before-and-after samples are used rather than a single measurement.
Who might consider this test?
- Because the comparison depends on paired samples and timing, a clinician typically guides when each sample should be collected.
Test details
| Quest code | 15903 |
|---|---|
| Methodology | Multi-Analyte Immunodetection |
| Sample type | 0.5 mL serum |
| Collection | Quest patient service center |
Related tests and panels
Measures IgG, IgA, and IgM antibodies to beta-2-glycoprotein I, related to…
Measures C-reactive protein, a blood marker associated with inflammation in the…
Measures high-sensitivity C-reactive protein (hs-CRP), an inflammation marker…
Quest resources
Additional details
What this test looks at
The test reports IgG antibody levels to four Neisseria meningitidis serogroups: A, C, W-135, and Y. Quest describes comparing paired samples, collected before and after vaccination, using multi-analyte immunodetection, with a two-fold or greater rise in at least two serogroups considered an adequate response.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures serum IgG antibodies to four Neisseria meningitidis serogroups, A, C, W-135, and Y, using multi-analyte immunodetection.
How is the sample collected?
The test uses paired 0.5 mL serum samples, typically collected before and after vaccination.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
What counts as an adequate vaccine response on this test?
Quest describes a two-fold or greater rise in antibody levels in at least two of the four serogroups as the expected pattern for an adequate response.
How long do antibody levels from vaccination last?
Quest reports that antibody levels typically peak about one month after vaccination and decline markedly by two years afterward.
How much does the Meningitidis Neisseria, IgG, Vaccine Response, MAID test cost?
The cash price at Celio Health is $425. That covers the physician's order and sample collection at a Quest patient service center — no insurance is needed and there's no separate doctor's visit to pay for.