HLA-B27 Antigen Test
The HLA-B27 Antigen test measures whether the HLA-B27 antigen is present on white blood cells, using flow cytometry on a whole blood sample. It is a marker associated with ankylosing spondylitis and Reiter's disease.
About this test
HLA-B27 is an antigen found on white blood cells. Quest describes it as present in most people with ankylosing spondylitis and in many people with Reiter's disease, and notes that ankylosing spondylitis occurs much more often in people who carry this antigen than in people who do not.
The test itself simply reports whether the antigen is present or absent; it does not, on its own, establish either condition. A clinician reads the result together with symptoms, imaging and other findings, since many people who carry the HLA-B27 antigen never develop either condition.
Test details
| Quest code | 528 |
|---|---|
| Methodology | Flow Cytometry |
| Sample type | 5 mL whole blood |
| Collection | Quest patient service center |
Reference range
Negative
Reference ranges are general guidance. The range printed on your own laboratory report is the one that applies to your result.
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Quest resources
Additional details
What this test looks at
The test reports the presence or absence of the HLA-B27 antigen on white blood cells, using flow cytometry on a whole blood sample collected in a sodium heparin tube.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures whether the HLA-B27 antigen is present on white blood cells, using flow cytometry on a whole blood sample.
How is the sample collected?
The test uses a whole blood sample, collected in a sodium heparin tube, from a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Does having the HLA-B27 antigen mean I have ankylosing spondylitis?
No. Many people who carry the HLA-B27 antigen never develop ankylosing spondylitis or Reiter's disease. A clinician reads this result together with symptoms and other findings.
Is this test used on its own to establish these conditions?
No. It reports whether the antigen is present, and Quest describes it as a marker associated with these conditions rather than a stand-alone answer. A clinician interprets it in context.
What does a HLA-B27 Antigen test cost without insurance?
$149. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.