CCP (Cyclic Citrullinated Peptide) Antibody (IgG) Test
The CCP antibody IgG test measures a class of antibodies associated with rheumatoid arthritis in a blood sample. It is one of several markers clinicians weigh together when evaluating this condition, not a stand-alone answer.
About this test
Cyclic citrullinated peptide (CCP) antibodies are IgG antibodies that react to a synthetic citrulline-containing peptide. Quest describes them as associated with rheumatoid arthritis and useful in telling it apart from other conditions, such as hepatitis C infection, that can cause similar antibody patterns.
The test is run on a small serum sample using an immunoassay method. CCP antibody IgG is one of the components included in rheumatoid arthritis classification criteria, alongside rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate, so it is typically read together with those results rather than by itself.
Test details
| Quest code | 11173 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 1 mL serum |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports the level of IgG antibodies to cyclic citrullinated peptide in serum. Quest also lists it under names such as Citrullinated Peptide (CCP) IgG and Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG, which refer to the same measurement.
How it's often used alongside other tests
CCP antibody IgG is described as one part of the rheumatoid arthritis classification criteria, which also include rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate. Most people with rheumatoid arthritis test positive for this antibody, while it is uncommon in people without the condition, which is part of why clinicians find it useful when read alongside the other criteria rather than on its own.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the CCP antibody IgG test measure?
It measures the level of IgG antibodies against cyclic citrullinated peptide (CCP) in a serum sample, using an immunoassay method. These antibodies are associated with rheumatoid arthritis.
How is the sample collected?
The test uses a small serum sample from a routine blood draw at a Quest Diagnostics patient service center.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Is CCP antibody IgG the same as rheumatoid factor?
No. They are different markers. CCP antibody IgG is described as one of several components in rheumatoid arthritis classification criteria, which also include rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate.
Can this test diagnose rheumatoid arthritis on its own?
No. It is one of several markers clinicians weigh together, alongside symptoms, history and other test results, when evaluating rheumatoid arthritis.
Can I get the Cyclic Citrullinated Peptide Antibody test without a doctor's visit or insurance?
Yes. The $185 cash price includes an independent physician's order, so no referral is needed, and insurance is never involved.