DNA (ds) Antibody Test
The DNA (ds) antibody test measures antibodies to double-stranded DNA in a serum sample. Quest describes these antibodies as associated with active systemic lupus erythematosus and some cases of mixed connective tissue disease.
About this test
Double-stranded DNA (dsDNA) antibodies are detected in serum using an immunoassay method. Quest associates the presence of these antibodies with active systemic lupus erythematosus, and notes they are also seen in some cases of mixed connective tissue disease.
As with other single antibody markers, a dsDNA antibody result is read in context. A positive result does not by itself establish a specific diagnosis; a clinician looks at it alongside symptoms, history, and other laboratory findings.
Test details
| Quest code | 255 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 1 mL serum |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports whether double-stranded DNA (dsDNA) antibodies are present in a serum sample, using an immunoassay method. Quest also lists this product as Native DNA, dsDNA, Double-Stranded DNA Antibody, and Anti-DNA (dsDNA), all referring to the same measurement.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the dsDNA antibody test measure?
It measures whether double-stranded DNA (dsDNA) antibodies are present in a serum sample, using an immunoassay method. Quest associates these antibodies with active systemic lupus erythematosus and some cases of mixed connective tissue disease.
How is the sample collected?
The test uses a serum sample from a routine blood draw at a Quest Diagnostics patient service center.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Does a positive dsDNA antibody result mean I have lupus?
No. A positive result is one piece of information a clinician reads alongside symptoms, history and other laboratory findings; it does not establish a diagnosis on its own.
What other names does Quest use for this test?
Quest also lists it as Native DNA, dsDNA, Double-Stranded DNA Antibody, and Anti-DNA (dsDNA); all refer to the same measurement.
Can I get the Antibody DNA test without a doctor's visit or insurance?
Yes. The $200 cash price includes an independent physician's order, so no referral is needed, and insurance is never involved.