Tissue Transglutaminase (tTG) Antibody (IgA) Test
The tTG IgA test measures Immunoglobulin A antibodies against tissue transglutaminase in a blood sample. Quest describes it as useful in diagnosing gluten-sensitive enteropathies, including Celiac Sprue Disease, and the related skin condition dermatitis herpetiformis.
About this test
Tissue transglutaminase IgA antibody is the antibody class most commonly measured when evaluating gluten-sensitive enteropathies. Quest lists this test under several names, including tTG Antibody, tTG IgA and Transglutaminase, Tissue Antibody IgA, and it is analyzed using an immunoassay method on a serum sample.
The result reports IgA antibody levels only; Quest does not describe this particular product as pairing an IgG measurement alongside it. Because IgA deficiency can make an IgA-based antibody result less informative, a clinician weighs that possibility together with the test result and the person's broader clinical picture.
Who might consider this test?
- People who talk with their clinician about this test are usually being evaluated for celiac disease or dermatitis herpetiformis.
Test details
| Quest code | 8821 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 1 mL serum |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports the level of IgA antibody against tissue transglutaminase in a serum sample, measured by immunoassay. Quest lists it under several names, including tTG Antibody, tTG IgA, and Transglutaminase, Tissue Antibody IgA, that all refer to this same measurement.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the tTG IgA test measure?
It measures Immunoglobulin A (IgA) antibodies against tissue transglutaminase in a serum sample, using an immunoassay method.
How is the sample collected?
The test uses a 1 mL serum sample from a routine blood draw at a Quest Diagnostics patient service center.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
What conditions is this test used to help diagnose?
Quest lists it as useful in diagnosing gluten-sensitive enteropathies, including Celiac Sprue Disease, and an associated skin condition called dermatitis herpetiformis.
Why is this test also called tTG Antibody or tTG IgA?
Quest lists this same tissue transglutaminase IgA antibody test under several names, including tTG Antibody, tTG IgA, and Transglutaminase, Tissue Antibody IgA.
Can I get the Tissue Transglutaminase Antibody test without a doctor's visit or insurance?
Yes. The $85 cash price includes an independent physician's order, so no referral is needed, and insurance is never involved.