Tissue Transglutaminase (tTG) Antibodies (IgG, IgA) Test
This test measures both IgA and IgG antibodies against tissue transglutaminase in a blood sample. Quest describes it as used in diagnosing gluten-sensitive enteropathies such as Celiac Sprue Disease and the related skin condition dermatitis herpetiformis.
About this test
Tissue transglutaminase antibodies are markers the immune system makes in gluten-sensitive enteropathies. This test reports both the IgA and IgG antibody classes from one serum sample, analyzed using immunoassay methodology. Quest also lists it under the alias Transglutaminase IgG IgA.
Quest notes that the IgG version is useful in patients who are IgA-deficient, since an IgA-based antibody test can be less informative in that group. Running both antibody classes together is intended to provide additional diagnostic support for gluten-sensitive enteropathies beyond what the IgA test offers on its own, particularly for IgA-deficient patients.
Who might consider this test?
- Ordering both antibody classes together is one way Quest describes clinicians addressing that gap.
Test details
| Quest code | 11073 |
|---|---|
| Methodology | Immunoassay |
| Sample type | 1 mL serum |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports two related values from one serum sample: IgA and IgG antibodies against tissue transglutaminase, both measured by immunoassay. Quest lists the combined test under the alias Transglutaminase IgG IgA, alongside its formal name.
How it's often used alongside other tests
Quest describes the IgG antibody as providing additional diagnostic support beyond the IgA antibody alone, particularly in patients who are IgA-deficient. Because of that, a clinician may read the two values together rather than ordering the IgA antibody by itself.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures both IgA and IgG antibodies against tissue transglutaminase in a single serum sample, analyzed using immunoassay methodology.
How is the sample collected?
The test uses a 1 mL serum sample from a routine blood draw at a Quest Diagnostics patient service center.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Why measure both IgA and IgG tTG antibodies?
Quest notes that the IgG antibody is useful in patients who are IgA-deficient, since it can provide diagnostic support for gluten-sensitive enteropathies that an IgA-only result might miss in that group.
What conditions is this test used to help diagnose?
Quest lists it as used in diagnosing gluten-sensitive enteropathies such as Celiac Sprue Disease and the related skin condition dermatitis herpetiformis.
What does a Tissue Transglutaminase Antibodies test cost without insurance?
$275. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.