Celiac Disease Comprehensive Panel
The Celiac Disease Comprehensive Panel measures tissue transglutaminase IgA antibodies and total immunoglobulin A in a blood sample. Quest describes these antibodies as part of the immune response to gluten that can damage the small intestine, and the panel is used to help evaluate celiac disease and to help follow how well a gluten-free diet is being followed.
About this panel
Celiac disease is an immune response to gluten in people who are genetically sensitive to it. This panel is described by Quest as detecting elevated celiac disease antibodies in the blood, which indicate that immune response.
Quest describes diagnosis of celiac disease as relying mainly on a small intestine biopsy, with this kind of serologic antibody testing serving a supportive role. Because antibody levels tend to fall with consistent gluten avoidance, the panel is also described as a way to help assess how closely a gluten-free diet is being followed over time.
What's included
3 analytes, ordered together in a single draw.
- IMMUNOGLOBULIN A
- INTERPRETATION
- TISSUE TRANSGLUTAMINASE AB, IGA
Test details
| Quest code | 19955 |
|---|---|
| Methodology | Immunoassay • Immunoturbidimetric |
| Sample type | 5 mL serum |
| Collection | Quest patient service center |
Related tests and panels
Measures IgG and IgA antibodies to deamidated gliadin peptides, used in celiac di…
Quest resources
Additional details
What this test looks at
The panel reports tissue transglutaminase IgA antibody, total immunoglobulin A, and an interpretation. Tissue transglutaminase IgA is the primary antibody Quest associates with celiac disease; total IgA is measured alongside it because a person with low overall IgA can have a falsely low tTG-IgA result.
How it's often used alongside other tests
Quest's reflex rules describe how the panel can expand depending on the initial results. If tissue transglutaminase IgA antibody is detected, the lab can add an endomysial antibody screen, and a positive screen can lead to an endomysial antibody titer. If total IgA comes back below the expected range for age, the lab instead reflexes to a tissue transglutaminase IgG antibody test, since IgA-based testing is less reliable when overall IgA is low.
This test isn't orderable through the store yet. Requesting it tells us you want it and puts you on the list to be told when that changes — there is no charge and no commitment, and requesting does not place an order.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the Celiac Disease Comprehensive Panel measure?
It measures tissue transglutaminase IgA antibodies and total immunoglobulin A in a serum sample, using immunoturbidimetric immunoassay methods. These antibodies are part of the immune response to gluten that Quest associates with celiac disease.
How is the sample collected?
The test uses a serum sample from a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Can this panel diagnose celiac disease on its own?
Quest describes diagnosis as relying mainly on a small intestine biopsy, with antibody testing like this panel serving a supportive role in that evaluation.
Why does the panel sometimes lead to additional antibody tests?
Quest's reflex rules add an endomysial antibody screen or titer depending on the tissue transglutaminase IgA result, and switch to a tissue transglutaminase IgG test when total IgA is low, since that can affect how the IgA-based result is interpreted.