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Lab test

Iodine, Serum/Plasma Test

This test measures the level of iodine in a serum or plasma sample. Iodine is an essential element required for thyroid hormone production, and Quest describes this measurement as an index of dietary intake adequacy and of iodine overload.

Blood drawQuest patient service center

About this test

The test is performed using Inductively Coupled Plasma/Mass Spectrometry on a serum or plasma sample collected in a trace metal-free tube, which avoids contaminating the sample with iodine from ordinary collection materials. Iodine is required for the body to produce thyroid hormone, and Quest describes the result as reflecting dietary intake.

Quest notes this test may be ordered to check whether dietary iodine intake is adequate, or to evaluate possible iodine overload, particularly overload associated with iodine-containing drugs such as Amiodarone. A clinician reads the result in the context of diet, medication history and any thyroid-related findings.

Who might consider this test?

  • Often looking at dietary iodine intake
  • Are being evaluated for possible iodine overload
  • Including overload connected to an iodine-containing medication such as Amiodarone

Test details

Quest code16599
MethodologyInductively Coupled Plasma/Mass Spectrometry
Sample type1 mL serum; or; 1 mL plasma
CollectionQuest patient service center

Reference range

52-109 mcg/L

Reference ranges are general guidance. The range printed on your own laboratory report is the one that applies to your result.

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Quest resources

Additional details

What this test looks at

The test reports the level of iodine in serum or plasma, collected in a trace metal-free tube to keep the sample free of outside iodine contamination, and analyzed using Inductively Coupled Plasma/Mass Spectrometry.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this test measure?

It measures the level of iodine in a serum or plasma sample, using Inductively Coupled Plasma/Mass Spectrometry.

How is the sample collected?

The test uses a serum or plasma sample, collected in a trace metal-free tube, from a routine blood draw.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Why would iodine overload be a concern?

Quest notes this test may be used to evaluate possible iodine overload, particularly overload associated with iodine-containing drugs such as Amiodarone.

Does this test reflect thyroid hormone levels directly?

No. It measures iodine, an element the body needs to make thyroid hormone, rather than thyroid hormone itself. Thyroid-specific tests are separate.

How much is a Iodine, Serum/Plasma test?

$105, paid once at checkout. The price includes the physician's order this test requires and sample collection at a Quest patient service center.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.