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Lab test

PTH, Intact (ICMA) and Ionized Calcium Test

This panel measures intact parathyroid hormone (PTH), total calcium and ionized calcium from blood samples. Quest describes it as used in evaluating hyperparathyroidism and hypercalcemia.

Quest patient service center

About this test

PTH is measured by immunoassay on plasma collected in an EDTA tube. Total calcium is measured by spectrophotometry on serum, and ionized calcium is measured with an ion-specific electrode on serum from a gel barrier tube.

Quest lists this combination as used in evaluating primary and secondary hyperparathyroidism, in working through the possible causes of hypercalcemia, and in distinguishing hypercalcemia caused by primary hyperparathyroidism from hypercalcemia related to malignant disease.

Who might consider this test?

  • People who consider this panel are usually already being evaluated for an abnormal calcium level or a suspected parathyroid condition.
  • Because PTH is interpreted differently depending on whether calcium is high, low or normal, Quest reports the two together rather than PTH alone.

Test details

CollectionQuest patient service center

Quest resources

Additional details

What this test looks at

The panel reports three values: intact PTH, total calcium and ionized calcium, each measured by a method suited to what it detects and each collected in its own specimen tube.

This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this panel measure?

It measures intact PTH, total calcium and ionized calcium from separate blood samples.

How is the sample collected?

PTH uses plasma from an EDTA tube, total calcium uses serum, and ionized calcium uses serum from a gel barrier tube.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Why are PTH and calcium reported together?

Quest lists this combination as used in evaluating hyperparathyroidism, working through the causes of hypercalcemia, and distinguishing hypercalcemia caused by primary hyperparathyroidism from hypercalcemia related to malignant disease.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.