Deoxypyridinoline Crosslinks, Urine Test
The deoxypyridinoline crosslinks test measures a bone breakdown marker in a first morning urine sample. Quest describes it as a way to monitor response to antiresorptive therapy in postmenopausal women and people with osteoporosis.
About this test
Deoxypyridinoline crosslinks appear in urine when bone tissue is broken down, and the test reports their level relative to creatinine in a first morning sample. Quest describes this measurement as useful for monitoring response to antiresorptive therapy rather than for diagnosing bone conditions.
The sample is analyzed using a quantitative enzyme immunoassay. Quest is explicit that this test does not replace bone mineral density (BMD) screening, which is the test used to diagnose osteoporosis.
Test details
| Quest code | 36614 |
|---|---|
| Methodology | Quantitative Enzyme Immunoassay |
| Sample type | 3.5 mL aliquot from a well-mixed, first morning voided urine |
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports deoxypyridinoline crosslinks measured against urine creatinine in a first morning voided urine sample. Quest also lists it as D-Pyrilinks, DPD Cross Link Urine and Urinary Crosslinks DPD.
How it's often used alongside other tests
Quest describes this test as a way to monitor response to antiresorptive therapy in postmenopausal women and people with osteoporosis, and notes explicitly that it does not replace bone mineral density (BMD) screening, which remains the test used to diagnose osteoporosis.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It measures deoxypyridinoline crosslinks relative to urine creatinine, using a quantitative enzyme immunoassay, in a first morning urine sample.
How is the sample collected?
The test uses a portion of a well-mixed, first morning voided urine sample, collected at home or at a patient service center.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Does this test diagnose osteoporosis?
No. Quest states this test does not replace bone mineral density (BMD) screening, which is used to diagnose osteoporosis. It's intended for monitoring response to antiresorptive therapy.
Who uses this test to monitor therapy?
Quest describes it for monitoring response to antiresorptive therapy in postmenopausal women and people with osteoporosis.
How much does the Deoxypyridinoline Crosslinks, Urine test cost?
The cash price at Celio Health is $300. That covers the physician's order and sample collection at a Quest patient service center — no insurance is needed and there's no separate doctor's visit to pay for.