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Lab test

Epstein-Barr Virus (EBV) Early Antigen D Antibody (IgG) Test

This test measures IgG antibody against Epstein-Barr virus Early Antigen D in a serum sample. It is one antibody among several that clinicians use to help place where a person may be in the course of an EBV infection.

Blood drawQuest patient service center

About this test

Epstein-Barr virus (EBV) Early Antigen D antibody, IgG, is measured from a 1 mL serum sample using immunoassay methodology. Quest also lists this test as EBV Early Antigen Diffuse Antibody or EBV EA-D Antibody.

EBV infection is associated with infectious mononucleosis, usually a self-limiting illness in children and young adults, and has also been linked to lymphoproliferative disorders, including tumors. Persistently elevated levels of this antibody suggest reactivation or ongoing persistence of EBV infection, which is why a clinician reads it in the context of a person's history and other results.

Who might consider this test?

  • Because this antibody is typically transient, its presence or absence adds timing information the more persistent EBV antibodies do not.

Test details

Quest code15447
MethodologyImmunoassay
Sample type1 mL serum
CollectionQuest patient service center

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Quest resources

Additional details

What this test looks at

The test reports one value: the level of IgG antibody to EBV Early Antigen D in serum. It generally becomes detectable within about a month of illness and fades within three to four months in most people. A result that stays elevated longer than expected suggests the virus has reactivated or is persisting, information a clinician weighs alongside other EBV antibody results and a person's history.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this test measure?

It measures the level of IgG antibody against Epstein-Barr virus Early Antigen D in a serum sample, using immunoassay methodology.

How is the sample collected?

The test uses a serum sample from a routine blood draw at a Quest Diagnostics patient service center.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Is this the same as EBV Early Antigen Diffuse Antibody?

Yes. Quest also lists this test as EBV Early Antigen Diffuse Antibody or EBV EA-D Antibody; these all refer to the same measurement.

What does a persistently elevated result suggest?

Persistently elevated levels suggest reactivation or ongoing persistence of EBV infection. A clinician interprets this alongside a person's history and other antibody results.

How much is a EBV Virus Early Antigen D Antibody test?

$160, paid once at checkout. The price includes the physician's order this test requires and sample collection at a Quest patient service center.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.