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Lab test

Alpha-Galactosidase, Serum Test

This test measures the activity level of the alpha-galactosidase enzyme in a blood serum sample. Quest describes it as the preferred screening test for Fabry disease in males.

Quest patient service center

About this test

Alpha-galactosidase is an enzyme, and this test measures its activity level in a frozen serum sample using a fluorometric method. Quest describes it as the preferred screening test for Fabry disease and notes it is used in evaluating Fabry disease in males.

Quest also notes that this test is not useful for evaluating a meat or meat-derived product allergy, a distinction worth knowing because alpha-galactosidase is sometimes confused with alpha-gal, the carbohydrate associated with that kind of allergy.

Test details

CollectionQuest patient service center

Quest resources

Additional details

What this test looks at

The test reports the activity level of the alpha-galactosidase enzyme in serum. Quest lists this product under several names tied to Fabry disease, including Ceramide Trihexosidase, GLA Deficiency, and Anderson-Fabry Disease, which all refer to the same measurement.

This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this test measure?

It measures the activity level of the alpha-galactosidase enzyme in a serum sample.

How is the sample collected?

The test uses a 2 mL frozen serum sample, analyzed using a fluorometric method.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Is this test used for food allergy evaluation?

No. Quest notes this test is not useful for evaluating a meat or meat-derived product allergy.

Who is this test typically used for?

Quest describes it as the preferred screening test for Fabry disease and notes it is used in evaluating Fabry disease in males.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.