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Lab test

Progesterone (LC/MS) Test

This test measures progesterone in a serum sample using chromatography/mass spectrometry (LC/MS). Progesterone is a hormone linked to ovulation and, during pregnancy, to placental function.

Blood drawQuest patient service center

About this test

Progesterone is measured in a 1 mL serum sample using a chromatography/mass spectrometry method, sometimes referred to as LC/MS.

This test may be used to help establish whether a functioning corpus luteum is present, to support findings from basal body temperature tracking related to ovulation, to give an indication of the day of ovulation, or to assess placental function during pregnancy.

Who might consider this test?

  • Often working through a fertility or cycle-related question -- for example
  • Confirming that ovulation has occurred
  • Narrowing down when it happened

Test details

Quest code17183
MethodologyChromatography/Mass Spectrometry
Sample type1 mL serum
CollectionQuest patient service center

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Additional details

What this test looks at

The test reports a single value: the concentration of progesterone in serum, measured using chromatography/mass spectrometry. A clinician reads the result in the context of the reason it was ordered, whether that is confirming ovulation, timing it, or assessing placental function in pregnancy.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does the Progesterone, LC/MS test measure?

It measures the concentration of progesterone in a serum sample using chromatography/mass spectrometry.

How is the sample collected?

Through a routine blood draw that collects a 1 mL serum sample.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Why might someone order a progesterone test around ovulation?

It may be used to help establish whether a functioning corpus luteum is present, to support basal body temperature findings, or to give an indication of the day of ovulation.

How much does the Progesterone, LC/MS test cost?

The cash price at Celio Health is $250. That covers the physician's order and sample collection at a Quest patient service center — no insurance is needed and there's no separate doctor's visit to pay for.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.