First Trimester Screen, Hyperglycosylated hCG (h-hCG)
The First Trimester Screen (h-hCG) measures hyperglycosylated hCG, a hormone marker, in a serum sample taken starting around nine weeks of pregnancy. Quest describes it as part of a screening approach for Down syndrome and trisomy 18, read together with other pregnancy-related information rather than on its own.
About this test
Hyperglycosylated hCG is one hormone marker measured from a serum sample using chemiluminescence immunoassay methodology. Quest lists this test alongside a wide set of related names and inputs — including Invasive Trophoblast Antigen (ITA), Nuchal Translucency (NT), Pregnancy-associated Plasma Protein-A (PAPP-A), and the broader label MSS, 1st Trimester, Down Syndrome and Trisomy 18 Screen — reflecting that first-trimester screening combines a maternal blood marker with other pregnancy details, such as gestational age and ultrasound findings, into a single risk assessment.
Who might consider this test?
- A screening test rather than a diagnostic one
- A result describes a risk level
Test details
| Collection | Quest patient service center |
|---|
Quest resources
Additional details
How it's often used alongside other tests
This screen combines the h-hCG blood measurement with other information Quest lists alongside it, such as PAPP-A, nuchal translucency measurements, gestational age and maternal details. Because first-trimester screening works by combining several inputs into one risk estimate, no single piece — including the h-hCG level itself — is read in isolation.
This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this screen measure?
It measures hyperglycosylated hCG, a hormone marker, in a serum sample, using chemiluminescence immunoassay methodology.
How is the sample collected?
The test uses a serum sample from a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
When in pregnancy is this screen done?
Quest lists it as starting around nine weeks of gestation.