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Lab test

Lp-PLA2 Activity Test

The Lp-PLA2 Activity test measures the activity of Lp-PLA2, an enzyme that has been found localized in atherosclerotic plaques. Quest describes it as used along with traditional cardiovascular risk factor measures to help identify people at higher risk of cardiovascular events.

Blood drawFasting preferredQuest patient service center

About this test

Lp-PLA2 is an inflammatory enzyme that circulates mainly bound to LDL cholesterol and has been found localized in atherosclerotic plaques. Quest describes studies showing Lp-PLA2 activity is an independent predictor of coronary heart disease and stroke in the general population.

The test is run on a serum sample using an enzyme assay on an automated chemistry platform. Because it is described as used along with traditional risk factor measures, clinicians typically read the result together with the rest of a person's cardiovascular risk picture rather than on its own.

Test details

Quest code94267
MethodologyEnzymatic Assay
Sample type1 mL serum
Patient preparationFast before your blood draw if you can; water is fine.
CollectionQuest patient service center

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Quest resources

Additional details

What this test looks at

The test reports one value: Lp-PLA2 activity in a serum sample. Quest also lists it under the alias PAF-AH, and the two terms refer to the same measurement.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does the Lp-PLA2 Activity test measure?

It measures the activity of Lp-PLA2, an enzyme that circulates mainly bound to LDL cholesterol, using an enzyme assay on a serum sample.

How is the Lp-PLA2 sample collected?

The test uses a serum sample from a routine blood draw.

Do I need to prepare for this test?

Fast before your blood draw if you can; water is fine. This is the preparation Quest publishes for this test; if your clinician gives you different instructions, follow theirs.

Is Lp-PLA2 the same as PAF-AH?

Yes. Quest lists PAF-AH as an alias for this same Lp-PLA2 activity measurement.

What does a Lp-PLA2 Activity test cost without insurance?

$75. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.