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Lab test

Apolipoprotein A1 Test

The apolipoprotein A1 test measures the concentration of apolipoprotein A1, the primary protein associated with HDL cholesterol, in a blood sample. Clinicians may include it in a cardiovascular risk evaluation alongside other lipid results.

Blood drawQuest patient service center

About this test

Apolipoprotein A1 is the main protein carried by HDL cholesterol, often called the "good" cholesterol. Increased apolipoprotein A1 concentrations, like increased HDL cholesterol, are associated with reduced risk of cardiovascular disease, which is why this measurement may be included in a cardiovascular risk evaluation.

The test uses a 1 mL serum sample, analyzed with an immunoturbidimetric method to determine the apolipoprotein A1 concentration. It reports a single value that a clinician reads alongside other lipid results and personal history rather than on its own.

Who might consider this test?

  • It may come up alongside other lipid or apolipoprotein testing rather than as a stand-alone check.

Test details

Quest code5223
MethodologyImmunoturbidimetric
Sample type1 mL serum
CollectionQuest patient service center

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Additional details

What this test looks at

The test reports one value: the concentration of apolipoprotein A1 in serum. Apolipoprotein A1 is the primary protein associated with HDL cholesterol, and the measurement is produced using an immunoturbidimetric method on a 1 mL serum sample.

How it's often used alongside other tests

Apolipoprotein A1 is described as a measurement that may be included in cardiovascular risk evaluation, considered alongside HDL cholesterol and the rest of a lipid picture. A single value does not stand alone; a clinician weighs it with other results and history.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does the apolipoprotein A1 test measure?

It measures the concentration of apolipoprotein A1 in a serum sample, using an immunoturbidimetric method. Apolipoprotein A1 is the main protein associated with HDL cholesterol.

How is the sample collected?

The test uses a 1 mL serum sample collected through a routine blood draw.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Why might apolipoprotein A1 be ordered?

Because increased apolipoprotein A1, like increased HDL cholesterol, is associated with reduced cardiovascular disease risk, this measurement may be included as part of a broader cardiovascular risk evaluation.

How much is a Cardio Apolipoprotein A1 test?

$49, paid once at checkout. The price includes the physician's order this test requires and sample collection at a Quest patient service center.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.