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Lab test

Total Protein, Random Urine with Creatinine Test

This test measures total protein in a random urine sample together with creatinine, reporting a protein/creatinine ratio. It is used in the evaluation of kidney-related conditions and can be ordered through Celio Health.

Urine sampleQuest patient service center

About this test

The test uses a 10 mL random urine sample, collected without preservative, and analyzes it with colorimetric and spectrophotometric methods. It reports three results together: urine creatinine, total urine protein, and the protein/creatinine ratio calculated from them.

Quest describes elevated urine protein, known as proteinuria, as characteristic of renal disease, and notes it may be increased in conditions such as diabetes, hypertension, nephrotic syndrome and drug-related kidney toxicity. Pairing protein with creatinine in a ratio helps account for how concentrated or dilute a random urine sample is, rather than relying on a protein measurement alone.

Test details

Quest code1715
MethodologyColorimetric • Spectrophotometry
Sample type10 mL urine from a well-mixed random collection
CollectionQuest patient service center

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Quest resources

Additional details

What this test looks at

The panel reports three values from a single random urine sample: creatinine, total protein, and the protein/creatinine ratio. Quest lists elevated urine protein as characteristic of renal disease and notes it can also be seen with diabetes, hypertension, nephrotic syndrome and drug-related kidney toxicity.

Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.

Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.

Frequently asked questions

What does this test measure?

It measures total protein and creatinine in a random urine sample and reports a protein/creatinine ratio calculated from the two.

How is the sample collected?

The test uses a 10 mL urine specimen from a well-mixed random collection, without preservative.

Do I need to prepare for this test?

No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.

Why might a clinician order this test?

Quest lists elevated urine protein, or proteinuria, as characteristic of renal disease, and notes it may be increased in conditions such as diabetes, hypertension, nephrotic syndrome and drug-related kidney toxicity.

Why is protein measured together with creatinine?

Reporting a protein/creatinine ratio, rather than protein alone, is how Quest accounts for the concentration of a single random urine sample.

What does a Protein, Total, Random Urine with Creatinine test cost without insurance?

$105. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.

Last updated 2026-09-18 · How we write about lab testing

Educational content

This page is for general educational purposes only. It is not medical advice, and it is not a substitute for consultation with a qualified healthcare professional. Laboratory results should always be interpreted by a licensed clinician who knows your health history. If you have questions about your health or your results, talk with your doctor. If you think you may be experiencing a medical emergency, call 911.