Factor XI Mutation Analysis (Ashkenazi Jewish)
The Factor XI Mutation Analysis (Ashkenazi Jewish) test looks at DNA from a whole blood sample for specific mutations in the factor XI gene. Quest associates these mutations with a risk of prolonged bleeding, particularly during surgery, in people of Ashkenazi Jewish descent.
About this test
This test uses polymerase chain reaction and single nucleotide primer extension to examine DNA from a whole blood sample for known factor XI gene mutations associated with Ashkenazi Jewish ancestry. Quest describes these mutations as linked to a risk of prolonged bleeding, especially during surgery, and the test reports whether these specific genetic changes are present.
Who might consider this test?
- Specific to this ancestry
- The test is targeted rather than a general bleeding-risk screen
Test details
| Collection | Quest patient service center |
|---|
Quest resources
Additional details
This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does this test measure?
It analyzes DNA from a whole blood sample for known factor XI gene mutations, using polymerase chain reaction and single nucleotide primer extension, to check for changes Quest associates with prolonged bleeding risk, especially during surgery, in Ashkenazi Jewish individuals.
How is the sample collected?
The test uses a whole blood sample from a routine blood draw.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Is this the same as a Factor XI Deficiency test?
Quest lists Factor XI Deficiency, Plasma Thromboplastin Antecedent (PTA) Deficiency and Rosenthal Syndrome as alternate names for this test, since they describe the same underlying bleeding disorder this mutation analysis looks for.