Estrogens, Fractionated (LC/MS) Test
The Estrogens, Fractionated (LC/MS) test measures three main estrogens — estrone, estradiol and estriol — in a serum sample. Quest describes it as useful in evaluating estrogen status in situations such as menstrual or fertility concerns, pregnancy health, or suspected hormone-related conditions.
About this test
Estrone, estradiol and estriol are the three primary estrogens the body produces, and this panel reports each one from a single serum sample using chromatography/mass spectrometry. Reporting all three together, rather than a single estrogen, gives a clinician a fuller picture of estrogen activity than one marker alone.
Quest describes this panel as useful when evaluating sexual maturity, menstrual abnormalities, fertility abnormalities, fetal-placental health during pregnancy, estrogen-secreting tumors, and feminization syndromes in men. Because the reasons for ordering it vary widely, the panel is read in the context of the specific concern that prompted it, along with a person's history and other findings.
Who might consider this test?
- People who come to this panel are usually being evaluated for one of the specific situations Quest lists
- A menstrual or fertility concern
- A pregnancy-related question
Test details
| Quest code | 36742 |
|---|---|
| Methodology | Chromatography/Mass Spectrometry |
| Sample type | 2.5 mL serum |
| Collection | Quest patient service center |
Related tests and panels
Measures Anti-Mullerian Hormone (AMH), a hormone associated with ovarian reserve.
Quest resources
Additional details
What this test looks at
The panel reports three separate values from one serum sample: estrone, estradiol and estriol. Quest notes that estrogen levels can rise in situations such as pregnancy, precocious puberty, hyperthyroidism, liver cirrhosis, or certain ovarian, testicular or adrenal tumors, and can fall in situations such as a failing pregnancy, Turner syndrome, hypopituitarism, hypogonadism, menopause, Stein-Leventhal syndrome or anorexia nervosa. A single set of results does not point to any one of these on its own; a clinician interprets it alongside clinical and family history and a physical exam.
Order online and a physician order is included — no doctor's visit and no insurance needed. Your sample is collected at a Quest Diagnostics patient service center.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the Estrogens, Fractionated (LC/MS) test measure?
It measures three main estrogens — estrone, estradiol and estriol — in a serum sample, using chromatography/mass spectrometry. Reporting all three together gives a broader view of estrogen status than a single marker.
How is the sample collected?
The test uses a serum sample from a routine blood draw, collected in a red-top tube without gel.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Why might this panel be ordered?
Quest describes it as useful in evaluating sexual maturity, menstrual abnormalities, fertility abnormalities, fetal-placental health in pregnancy, estrogen-secreting tumors, and feminization syndromes in men.
What does a Estrogens, Fractionated, LC/MS test cost without insurance?
$225. Celio Health's price is a flat cash price and insurance is never billed: the required physician's order is included.