Cytochrome P450 2D6 Genotype Test
The CYP2D6 genotype test looks at variations in the CYP2D6 gene, a gene involved in how the body processes many common medications. It is a genetic test read by a clinician alongside a person's medication history, not a stand-alone answer.
About this test
CYP2D6 is a gene whose product plays a role in metabolizing many antidepressants, neuroleptics and cardiovascular drugs, so information about variants in this gene may be relevant to how these drug groups are processed. This test looks for eight gene variants associated with a pattern Quest describes as 'poor metabolizer', as well as gene duplication associated with an 'ultraextensive metabolizer' pattern.
The sample is a whole blood collection, analyzed using polymerase chain reaction and single nucleotide primer extension methods. Because the result describes a genetic pattern rather than a current lab value, it is typically read once and considered alongside a person's medication history rather than repeated over time.
Who might consider this test?
- Because the gene product is involved in processing several common drug groups, the reason for testing shapes how the result is used.
Test details
| Collection | Quest patient service center |
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Quest resources
Additional details
What this test looks at
The test reports on variants of the CYP2D6 gene, specifically eight variants Quest associates with a poor metabolizer pattern and gene duplication associated with an ultraextensive metabolizer pattern. It does not measure a drug level or a current physiological value; it reports a genetic pattern.
This test isn't part of the Celio Health store at the moment, so it can't be ordered or requested here. The test menu lists everything that can.
Laboratory results should always be interpreted by a licensed clinician who knows your health history. This page is information about a test, not medical advice.
Frequently asked questions
What does the CYP2D6 genotype test measure?
It looks at variations in the CYP2D6 gene, specifically variants associated with a poor metabolizer pattern and gene duplication associated with an ultraextensive metabolizer pattern. The CYP2D6 gene product plays a role in metabolizing many antidepressants, neuroleptics and cardiovascular drugs.
How is the sample collected?
The test uses a whole blood sample, analyzed using polymerase chain reaction and single nucleotide primer extension methods.
Do I need to prepare for this test?
No preparation instructions are listed for this test, though people follow any instructions their ordering clinician provides.
Why might someone get CYP2D6 genotyping?
Because the CYP2D6 gene product is involved in metabolizing many antidepressants, neuroleptics and cardiovascular drugs, information about a person's gene variants may be relevant to how these drug groups are processed, which is why it often comes up alongside a medication conversation with a clinician.
Is this the same as testing a drug level?
No. This test reports genetic variants in the CYP2D6 gene, not a measured drug concentration. A clinician interprets the genetic pattern alongside a person's medication history.